20+ years experience in biotech drug development from discovery research to analytical development for small molecule,
biologics (esp. antibodies & related modalities) and cell & gene therapies. Excellent communication skills to translate
technical topics to a diverse audience. Happiest being challenged to learn new things, solve hard problems and work across
disciplines. For example the most fun I had at ShapeTx was developing a Python class to analyze and visualize raw
charge determination mass spec data on intact AAV vectors because no such software was available at the time.
Prefer startups and will cheerfully do whatever needs to get done without drama. Seeking intellectual stimulation and the
opportunity to work on projects with positive impact more than a fancy title or high salary. I would also be interested in
entry level data scientist or analyst roles (or anything else that engages my strategic thinking / analytical brain.)
Temperature and humidity can have a marked effect on the stability of enveloped viruses themselves. e.g. coronaviruses & RSV, which comprise a subset of the viruses responsible for common colds. Another common cold virus, Rhinoviruses, are non-enveloped.
Which is true, but studies have shown that it is the increased time spent in the heated indoors that causes disease, not the time spent in the cold outdoors.
Ninja Nerds Medicine did an informative video* on the biochemistry & immunology of vitamin D in the context of SARS-CoV2 infection.
Vitamin D3 can be toxic at high doses. I live in Seattle and was at one point (years ago) tested and found deficient. My doc said many of his patients are. I was on 50k IU weekly for a few months to get back into range, and now I take 2k IU daily, with vitamin K2.
Anecdotally, I had something nasty with COVID-like symptoms in late 2019 and have had 1 minor cold since. I take other vitamin/mineral supplements, but passed on the experimental shots.
My Gates belt probably has >10k miles on it and is also silent. Coupled with a Rohloff, it is an essentially maintenance free drivetrain, save for changing the hub oil once per year.
Too bad that the Rohloff setup alone is like $1600, and the non-electric bikes with them tend to be >$5000. That Santos Cross Lite with the Lauf suspension fork does look pretty trick though. They have a helpful bike finder, though lots are not available in the US https://www.rohloff.de/en/service/search/bike-finder
I lost 2 jobs in biotech due to vaccine mandates. I'm consulting presently, but may need to completely change careers if the situation stays this way. That or find a startup where the founders care more about talent than optics.
I'm improving my python skills and studying machine learning, but I world rather be doing wet lab experiments.
At the end of the day your decision not to vaccinate is potentially putting other workers at risk so that's why its not being tolerated. If you find an employer that is willing to slack off on mandates, they are probably going to be slacking off on a lot of other employee protections that you'd like to have in your favor.
It is disappointing to see that so many (otherwise smart people) think that the first generation covid 'vaccines' (yes, the ones cdc had to change the definition of vaccine for) stop transmission. They don't - hence the argument that one should have to take them to 'protect' ones coworkers falls apart.
Be honest and reflect for a minute on how many people you know who have gotten covid recently. Do you think they all got it from unvaccinated people? Why are the majority of the mutations in spike protein then? Could it be selective pressure applied by a vaccine that was leaky from the start?
I'm sorry but mandating an experimental new drug is unethical, so yes I chose to adhere to my principles and I accept the consequences. My point was some people are out of the work force due to these unethical mandates.
ETA I have taken all other vaccines courses, participated in a different experimental vaccine clinical trial (where I felt comfortable making informed consent) and sat on the safety committees of at least 4 different biotech companies for some perspective.
This is not a study, but it does discuss the biochemistry of vitamin D and the role it plays in the immune system. It is left to the viewer to draw their own conclusions.
COVID-19 and Vitamin D | Association Between Vitamin D Deficiency and COVID-19
Yes, and in 1Q2017, the fund held $84.9E9. Meanwhile, in the US, gross private savings total $4.64 trillion, while personal savings total $1.06 trillion.(Sep 11, 2019)
What happens when a major bank goes under and completely depletes the FDIC fund? (e.g. Bank of America)
Another key aspect of monetary metals is lack of counter party risk. When you deposit money with BoA, it is no longer yours; you become an unsecured creditor of the bank. BoA's derivatives counter parties are senior to you, so they will get paid first if say interest rate swaps go against BoA, and they need to post more collateral to that counter party.
Also, the problem with rates 'normalizing' is the magnitude of outstanding Treasury debt, and the fraction of GDP that the interest payments represent. 5% would be devastating, even though historically, that is a typical rate.
A colleague and myself were pondering this today. He mentioned the 'bow', and general cultural aversion to physical contact. I found that interesting and plausible to consider.
I'm in Seattle. While there may be official "kits" for this, the protocol can be run in any competent lab set up for this type of assay. DNA primers specific for covid-19 would need to be ordered, but this is routine.
ETA: I'm having trouble locating positive control template sequences.
I am happy for S. Korea running 100,000+ tests, and embarrassed that the US has maybe run 1000s at this point. I also think that the virus is widely dispersed in the US and the best we can hope for is to keep the case load at a level manageable by our health care system. I'm pretty worried about that though.
I BLASTed all 4 2019-nCoV insert sequences and agree with that user. The sequences are short and found in many other proteins. It is appropriate to trim out the gaps (relative to the HIV sequences) in inserts 3 & 4, reducing the length of the query. In other words, we have 4 sequences of lengths: 6, 6, 8, & 12 amino acids, where the alphabet of naturally occurring amino acids is N=20. Amino acid frequency in proteins in non-uniform.
Remote: open to local in-person/hybrid or remote
Willing to relocate: not out of state
Technologies:
Résumé/CV: https://drive.google.com/file/d/1cBjdxf9qJqJQ1JEwrMm5ET8JEAY...Email: jldantzler+hn {at} gmail [dot] com
20+ years experience in biotech drug development from discovery research to analytical development for small molecule, biologics (esp. antibodies & related modalities) and cell & gene therapies. Excellent communication skills to translate technical topics to a diverse audience. Happiest being challenged to learn new things, solve hard problems and work across disciplines. For example the most fun I had at ShapeTx was developing a Python class to analyze and visualize raw charge determination mass spec data on intact AAV vectors because no such software was available at the time.
Prefer startups and will cheerfully do whatever needs to get done without drama. Seeking intellectual stimulation and the opportunity to work on projects with positive impact more than a fancy title or high salary. I would also be interested in entry level data scientist or analyst roles (or anything else that engages my strategic thinking / analytical brain.)
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