If someone released smallpox in NYC, it would be reasonable to quarantine the state (at the very least). There would be no argument about the government taking action to prevent the spread of virtually any pathogen, even the more pedestrian like multiple drug resistant TB.

People loose sight of reality when they think pure choice is involved though. Food, smoking, drugs... a lot of things only make sense if you're particularly educated, have friends/family struggling with something, are particularly empathetic, or have experienced them.