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Your argument doesn't make sense to me. If the chemical is harder to synthesize, then the receptors could be more sensitive, or bind longer. Why would our bodies evolve to use a messenger molecule that was so prohibitively expensive to make that we couldn't make enough of it?

These drugs are just changing the balances of existing pathways in our brains. They aren't creating new pathways. Either they are causing a substance that your body naturally limits to exist in higher quantities or lower quantities, keeping a messenger molecule from being removed as fast as it would be normally, or removed faster than normal.

So I agree with the parent, it is likely we can choose the tradeoffs, maybe needing to avoid predators and scavenge for food is not our priority anymore and we can turn off some of that so we can think more deeply. But chemically I doubt we can improve ourselves without any drawbacks.

But yes, technology in general, physical things, can have a more pure benefit, and we are already reaping the rewards of those benefits. A new macbook pro is likely to make me more productive while not interfering with my sleep :)



A net benefit is when we can synthesize drugs to allow us to adapt to externalities, which produce fewer side effects than benefits. Vaccines are a net positive in the presence of Polio. It could be argued that stimulants are a net positive in the presence of having to stare at a glowing rectangle and think in abstractions all day.




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