I understand your point, CLJS is a superset so it's ideal to understand the substrate that it's based on, it's more complex than just JS from that point of view but usability wise:

  lein new re-frame myapp
  lein run

or

  git clone https://github.com/jacekschae/shadow-reagent.git && cd shadow-reagent
  yarn install
  yarn dev

It is very much fire and go in a way that a typical JavaScript developer might grok