"The search engines run on databases of flights, prices, and seat availability, provided electronically over private networks by the 800 or so airlines of the world. The data is not directly available to the general public and access often must be negotiated with individual airlines. Flight data is updated daily or occasionally more frequently in the case of unexpected cancellations. Prices are updated about ten times a day, and seat availability continuously. A large portion of the flight, price and seat availability data, called published data, is used by all the major search engines, but a significant amount of private data is restricted." [0]

[0] http://www.demarcken.org/carl/papers/ITA-software-travel-com...