Ending alcohol prohibition effectively ended bootlegging I believe.
And for the most part, synthetic drugs are a reaction to prohibition, either to stay ahead of substances that have been scheduled as illegal or to provide drugs that can be made in-region to avoid the risk of smuggling. There is little organic demand for such drugs, and it would be much safer if people had access to pure forms of their drug of choice, i.e. cocaine and heroin
The newer "synthetic" (not all are actually fully synthetic) are partially a reaction to prohibition, at least most of the underground availability is a reaction. Some of these compounds have genuinely unique and interesting effects such as the auditory hallucinations of DiPT.
We really need to be able to explore these compounds and their pharmacodynamics, they can teach us so much about the brain
And for the most part, synthetic drugs are a reaction to prohibition, either to stay ahead of substances that have been scheduled as illegal or to provide drugs that can be made in-region to avoid the risk of smuggling. There is little organic demand for such drugs, and it would be much safer if people had access to pure forms of their drug of choice, i.e. cocaine and heroin