Python is a great language. Really nice to work with, if you don’t mind the premise (no static safety etc). It’s not really focused on UI though; packages exist but are kind of niche, I’d say. Not exotic: you have wrappers for Tkinter, Qt, WxWidgets etc. But most people writing serious native GUI apps avoid Python. I’ve always found Python GUIs slow and clunky.

Web is different for many reasons and there Python does well.