If you know how to take advantage of Qt, then you can make real-time video player, a real-time interactive graph or whatever else you can build with Qt's framework, then deploy it to Windows, Mac or Linux as if it were a native app.
I could never figure out what in QT you had to pay for when. That seems to have improved recently, looks like $3,600 per year to develop an app with QT.
Still a bit pricey to just play around with building something I think for someone small? But at least it's simpler, I could see buying something now - before it was impossible.
I never really got into QML (javascript type language). I'm not sure QT creator let's you form build with python? Downloading it is an evaluation thing as I look at it.
Are you suggesting not using BeeWare and using Qt instead? I only want to target Windows and macOS (I'm ignoring mobile.) For web I'm stuck in my ways and just go with Golang + server-side rendering (a bit of JS to make forms nicer.)
BeeWare and Qt are on different levels. It's like comparing a single guy on a scooter, doing a few deliveries on weekends, with FedEx. If you don't care about mobile, and you can deal with the licensing model of Qt and its wrappers, the choice is fairly obvious. Also, a lot of the knowledge around Qt is not really Python-specific, it's transferable to C++ (or the other bindings they have).
I like the guys behind BeeWare and they've done some very good work to address the awful Python story on mobile, but every time I try BeeWare it lacks a lot of functionality one would expect from production-ready toolkits. I'm sure things will improve with time, but I have a feeling someone with deeper pockets will eventually eat their lunch.
It is fair what other commenters have said about Qt being larger and used more production. However it is a pain - from licensing and code/technology point of view.
If you enjoy Go and/or like maintainable GUI code then Fyne is basically designed for you. The team is ambitious and always developing more features, plus there is now commercial support behind the project at https://fynelabs.com.