Have you used wxPython at all by chance? Curious how it compares in developer experience compared to PyQt/PySide. I like that it uses native widgets, but if Qt is that much easier to deal with I may just go that direction.
I actually looked into wxPython, admittedly only for a day or two to get the general idea behind it. It seemed complicated and not very mature at the time from my experience under linux (circa 2019 I want to say?)
But after spending the same amount of time with QT it definitely won out.