It's interesting that when it comes to cannabis they often do the opposite - that is they give subjects synthetic THC rather than the whole spectrum extract.
THC isolate is quite nasty - but the same amount of THC combined with CBD and other cannabinoids can work wonders.
I think there may be that if they isolated psilocybin, they could have missed other compounds that play a part in causing desired effects. Obviously this is a different substance than cannabinoids, but I think when it comes to plants it makes more sense to test it exactly how subjects use it rather than use synthetics.
edit: I hope I didn't cause offence to any mushroom - of course they are not plants, but I hope you get my point.
I think there may be that if they isolated psilocybin, they could have missed other compounds that play a part in causing desired effects. Obviously this is a different substance than cannabinoids, but I think when it comes to plants it makes more sense to test it exactly how subjects use it rather than use synthetics.
edit: I hope I didn't cause offence to any mushroom - of course they are not plants, but I hope you get my point.