I'm not sure how others do it, but how do you know when some one replies to your comment? Do you continually refresh the "Threads" page throughout the day?
I hope not; it seems woefully inefficient. Hopefully, there is a smarter, simpler way to do this.
Why receiving some non-sensual comments in a random time of a day do you consider efficient? Don't you have a life with more important events than some random dude's comment? Every time you are receiving the beep you are inevitably losing some context, maybe even get thrown off from "a stream".
For me reading HN is OK only before and after work, not instead. Maybe I would like to read some reactions to my ancient comments and I do not know where I have aquired additional +10 karma points over the last night, but theese are so unimportant things in my life that I will not lose anything if I dot't see it eventually.