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Fair points. But I think it's a pretty strong data point that the best known way to lose weight and keep it off in the long term is literally to cut/suck the fat cells out of your body (i.e., bariatric surgery). One would have to wonder what hormonal signals these fat cells are secreting in order to justify their continued existence and get fed...

The current second-best way are the GLP agonist drugs, which tweak hormones.

A very, very distant third is behavior modification/"changing diet and exercise regimen".

Now, to avoid gaining in the first place, you do have some points.

Someday soon, we're going to finally figure out the hideously complex orchestration of hunger, satiety and fat storage in the human body, and the obesity epidemic will finally end, and for the rest of human history this will be known as the "obesity era" /sigh

Lastly, speaking as a Mounjaro taker, you don't quite understand how this works. I do not have to exert willpower from the daily finite reserve I get in order to will it downwards. I do not have to change what I eat. I do not have to force myself to fast. I do not have to exercise (in fact, I exercise for other reasons, such as mood and mental clarity!). I do not have to calorie-track. I do not have to limit myself to specific foods. Here's what happens: I'm simply less hungry and reach satiety much quicker and that makes all the difference. I have far fewer "naggy" feelings of wanting to snack, I often don't finish meals, and I can use that spare willpower on other things in my life that need it, which is fantastic.



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