I considered using something like that, but my concern that it is going to ruin my muscle memory for the situations when I cannot use it - eg locked down environments at work. So I stick to whatever can be done with standard OS capabilities.
I've got a weird split thumb board like OP, and the muscle memory for a normal keyboard is fine. I think it helps that I mostly left qwerty intact, and messed with meta keys.
I'll throw another anecdote to the pile. I use a split, angled keyboard with a nonstandard keyboard layout for over a year now and I can use normal keyboards just fine.
It doesn't, I use a standard laptop keyboard and my weird-ass custom keyboard very interchangeably with zero trouble. Hell, I'm typing on a MacBook right now.
It's been a non-issue for me. I work on a standard qwerty laptop keyboard once or twice a month, but use a colemak split keyboard the rest. The worst thing that happens is I hit the wrong keys in my vim motions until my hands adjust to the standard keyboard again, but that stops happening after 5 minutes of typing.
