If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt.
I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
If I recall correctly there were some studies that actually showed endurance runners have higher type 2 diabetes risk. And the suspect cause was the diet, specifically the carb loading practice and the abuse of high sugar products during the activity. So the three categories may actually share the same baseline, insulin resistance. It was quite controversial when it emerged (see Tim Noakes story), not sure if it's more accepted these days.
Well yeah. You’re measuring the output to a multi-variate function. There should be no expectation that this one output drives other occasionally correlated outputs to other functions.
I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.