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bglazer
on June 9, 2024
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Gene therapy restores hearing to children with inh...
This is actually not totally correct. AAV’s form episomes, which are circular DNA structures that are basically extra chromosomes. The fact that AAV’s don’t randomly insert themselves into DNA makes them safer for clinical uses like this.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
toufka
on June 10, 2024
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And that’s why replies are helpful in these kind of explanations. My over-edits became wrong, and then an hour later, unfixable. bglazer is correct.
AAVs, unlike Lentiviruses, do NOT integrate.
bglazer
on June 10, 2024
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The reason I know this is I made the same mistake in a comment on a similar story a few weeks ago!
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519600/