I really want a new motherboard form factor that gets rid of the graphics card slot and assumes integrated graphics. It should also aim to reduce the height of the back panel a little bit. Maybe allow 4 DIMM slots (ECC preferred).

I just upgraded my Mellori-ITX to 64GB RAM and have a 5700G to drop in there. This is possibly the best SFF config you can do in an AM4 socket:

https://github.com/phkahler/mellori_ITX

BTW we need USB ports ON TOP so you can plug stuff in without pushing the PC around the desk. Storage, not permanently attached stuff.