I don't mix stacks that way because I tend to use OpenBSD for firewalls and I think it's a really bad idea to run my FW on the same physical box as my VM infrastructure, but I'm an old skool infosec wonk and we have ideas kids these days find antiquated & weird. But if you want to run with scissors most all the major virtualization stuff runs fine on a Protecli and so should anything that runs on top of them.