I think you always can. In the past you may lose some features / have some bugs. For recent kernel versions (>= 6.6) the only patches WSL kernels have is dxgkrnl + some hacky fixes for clock sync. Others are all in upstream already. So you'll just lose WSLg / CUDA passthrough and nothing else now.

Of course, there might be some regressions. They are usually only fixed (upstream) after WSL kernel gets upgraded and it starts to repro in WSL.