Sci-fi may be a slightly obvious answer; I think things like Blindsight would probably get tagged as literary fiction except that they are already genre fiction, say. That’ll probably happen sooner than 2200, tho; it has already started happening in edge cases where everyone kinda pretends it’s not sci-fi (Handmaid’s Tale, say).
I agree it's going to be SciFi, but maybe also some fantasy. So much of SciFi consists of speculative philosophy about the intersection of technology and society. Fantasy is somewhat similar if you abstract technology to include magic.
There are already debates as to whether Lord of the Rings is "literary" when it checks all the boxes.
