The idea works well with or without direct integration. You can have a cli agent read arbitrary state of any tmux session and have it drive work through it. I use it for everything from dev work to system debugging. It turns out a portable and callable binary with simple parameters is still easier to use for agents than protocols and skills: https://github.com/tikimcfee/gomuxai
There’s no special support needed; it’s just a bash command that any CLI agent can use. For agents that have skills, the corresponding skill helps leverage more easily. I’ll add that to the README