I'm been running the same XP install since 1/11/2004 as my primary machine. It has run on several mother board/cpus and been cloned across HD's numerous times too. It's going to be very difficult to give it up. I have a Vista and a Win8 boxes hooked up to the kvm here at the desk but the XP box is like an old friend.
Its firewalled and scanned regularly, browse with Chrome, careful with emails and downloads, so far so good? I don't do anything anything critical on it anyways. It will be retired soon though.