One thing I haven't discovered yet is whether the installation of 10 is going to be a brand new install rather than an upgrade. In other words, will it be necessary to reinstall all my applications after moving to 10?
The technical previews have offered an upgrade option, but that's not guarantee it will be included in the final version. Either way, it's almost always better to do a full reinstall for a major version like this.
I haven't used Win10 yet. I'm curious if they've rewritten some of the core components like they did for the 2003-2008 jump. Things like IIS, Task Scheduler engine, & Security (UAC elevation).
In the same vein... Windows Vista hadn't changed significantly since XP, or XP since 2000, or 2000 since NT 3.5.1, etc. It's all iterative and subject to perspective here.
But how "big" those changes are, is pretty subjective unless you're talking a pretty narrow context... the UI changed significantly in any number of areas between releases... if you have to access those a lot, that change is huge... to you. Frankly, I don't find any of them too different from each prior version... over time they're more significant.
Eh, even with constant upkeep and trimming of all non-essential processes/services, desktop Windows still begins to atrophy from day 1 in a way that one just does not see on *nix machines. Wish it weren't so but such is the price of Windows' legacy baggage.