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Not an expert, but creating a perennial vaccine depends on the mutation rate and which highly-conserved regions can be targeted.

One of the potential vaccines enrolling trial patients is made of mRNA that codes for the spike protein needed for entry to cells. [0] If that spike protein turns out to be highly-conserved, then the vaccine will have sticking power. If it's not, but there turn out to be evolutionary trade-offs to adapting around it, it could push the virus to become less aggressive.

0. https://clinicaltrials.gov/ct2/show/NCT04283461



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